This a TOUGH question... On what criteria do you chose to make the decision... Go with a classic great like Pyror or Carlin... someone more my generation like early Eddie Murphy, or a more current like Chapelle? Or some lesser known comic who's just fuckin briliant funny... I couldn't even pick just one...
Way too many like @JulsnMatt1028 said, it depends on what criteria, stand up, sitcom, film?
I like comedy that I can relate to, tickles my bone & leaves me laughing for days..
Margaret Cho
Adam Carolla
Ellen DeGeneres
George Carlin
Chelsea Handler
Kathy Griffin
Wanda Sykes
Eddie Murphy, he was good, better than his acting
Daniel Tosh makes me laugh hard, but so does Ellen, Wanda Sykes, Katt Williams, Margaret Cho, Kathy Griffin - as others have said, just too many to list. I love me some good stand up!